In 2024 HIV is a manageable condition, and people living with HIV are living longer, and will be encountered in health care settings outside of the HIV speciality. It is, therefore, important as a generalist or other specialist to have a grasp of how to identify and manage HIV drug-drug interactions. Additionally, due to effective treatment leading to fewer HIV-related deaths & improved survival, as well as ongoing diagnoses, there is an ageing cohort with potentially complex polypharmacy.